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There exist some studies on Nrf2, a key factor of oxidative stress, but on the one hand, Nrf2 has preventive oxidative and anti-inflammatory effects on normal cells, on the other hand, it can promote tumor metastasis and induce drug resistance [250, 251]

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[DOI] [PMC free article] [PubMed] [Google Scholar] [153].Muller EG, A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growth, Mol